Regarding The Case Of Acute Kidney Failure In Jakarta, What Medicine Is Praxion?

YOGYAKARTA – What kind of medicine is Praxion? Praxion is a trademark of paracetamol. This drug is often used to treat fever and pain in children.

The Praxion brand came under scrutiny after two new cases of atypical progressive acute kidney failure (GGPA) appeared in DKI Jakarta, consisting of one confirmed case and one suspected case.

A spokesperson for the Ministry of Health, Mohammad Syahril, said that one confirmed case of kidney failure was experienced by a child aged 1 year.

The child died after developing symptoms of acute kidney failure, including an inability to urinate (anuria).

Syahril said that the child was given paracetamol syrup under the Praxion brand to reduce fever.

"One confirmed case of kidney failure was a 1-year-old child who had a fever on January 25 2023 and was given fever-reducing syrup bought at a pharmacy under the Praxion brand," said Syahril in his official statement, quoted by VOI, Tuesday, February 7, 2023.

Previously, paracetamol syrup with the trademark Praxion had been declared safe for consumption by the Indonesian Food and Drug Supervisory Agency (BPOM).

Based on the verification results of the testing of medicinal raw materials for the period December 15-27 2022, Praxion syrup is included in an additional 176 products that meet the requirements, bringing the total safe drug to 508 medicinal syrup products from 49 Pharmaceutical Industries (IF).

After a new case of GGPA appeared in DKI Jakarta, the holder of the Praxion drug distribution permit carried out a voluntary recall or voluntary withdrawal of the drug from the market.

What Medicine is Praxion?

Praxion is a trademark of paracetamol syrup. This drug, manufactured by PT Pharos Indonesia, is commonly used to treat fever and pain symptoms in infants and children.

At least, there are three Praxion brand syrup products on the market, including:

• Praxion containing paracetamol 100 mg/ml, drops, box, bottle @ 15 ml.
• Praxion containing paracetamol 120 mg/5 ml, suspension, box, plastic bottle @ 60 ml.
• Praxion Forte containing paracetamol 250 mg/5ml, suspension, box, plastic bottle @ 60 ml.

This drug is thought to work directly on the temperature regulation center in the brain (hypothalamus) to lower body temperature when a person has a fever (antipyretic). In addition, Praxion which contains paracetamol also works by increasing the pain threshold (analgesic).

Rules for Using Praxion Drops

Praxion drops are used to treat fever or painful symptoms in children under two years. This drug contains paracetamol with a potency of 100 mg/ml.

The dosage is as follows:

• Infants under 1 year: 60 mg (0.6 ml dropper), 3-4 times a day or as directed by the doctor.
• Children aged 1-2 years: 60-120 mg (0.6 ml - 1.2 ml drops), 3-4 times a day or according to doctor's instructions.

Rules for Using Praxion Suspension

Praxion suspension is used to treat fever and painful symptoms in children aged 2-5 years. This medicine contains paracetamol 120 mg/5 ml. The dosage rules are:

• 0-1 years : 1/2 measuring spoon (2.5ml)
• 1-2 years: 1 measuring spoon (5ml), 3-4 times a day
• 2-6 years: 1-2 measuring spoons (5-10 ml), 3-4 times a day
• 6-9 years: 2-3 measuring spoons (10-15 ml), 3-4 times a day
• 9-12 years: 3-4 measuring spoons (15-20 ml), 3-4 times a day

Rules for Using Praxion Forte

While Praxion Forte is used to relieve fever and pain in children aged 6-12 years. This medicine contains paracetamol 250 mg/5 ml. The dosages are as follows:

• Children aged 2-5 years: 1-2 measuring spoons (5-10 ml), taken 3-4 times a day
• Children aged 6-12 years: 1-2 measuring spoons (5-10 ml), taken 3-4 times a day
• Children aged > 12 years: 2-4 measuring spoons (10-20 ml), taken 3-4 times a day

Storage of Praxion Drops, Praxion Suspension, and Praxion Forte is carried out at temperatures between 20-25 degrees Celsius.

Side Effects and Drug Interactions

Side effects that may occur while using Praxion, namely:

• Hematologic reactions
• Other skin and allergic reactions
• Contraindications

Praxion should not be used in patients who have the following conditions:

• Hypersensitivity to paracetamol
• Patients with liver or kidney failure
• Drug Interactions

Some drugs that can interact with Praxion include:

• Alcohol
• Oral anticoagulants
• Aspirin
• Phenobarbital

According to the United States Food and Drug Administration (FDA), Praxion syrup, which contains paracetamol, is included in category B. This means that it does not show a risk to the fetus based on studies on animal reproduction tests. However, there are no controlled studies on pregnant women.

Commercially available Praxion syrup has a green label with a solid black border around it. This means that this drug is included in the category of over-the-counter drugs, so it can be purchased easily without a doctor's prescription.

This is information about Praxion, which was highlighted after cases of acute kidney failure appeared in DKI Jakarta. What medicine is Praxion? Praxion is one of the trademarks of paracetamol syrup which is commonly used to reduce fever and treat pain in children.