The Side Effect Of Drinking Excessive Paracetamol, The Impact Can Be Fatal!

Paracetamol illustration (Pixabay/Hilbert)

YOGYAKARTA Paracetamol is the most commonly used drug to reduce fever and relieve mild pain, both in children and adults. Paracetamol is classified as a free and safe drug for all people. Even so, its use should not exceed the recommended dose. This is because the side effects of drinking paracetamol are quite fatal, namely causing liver damage and kidney failure.

For more details, let's look at the excessive side effects of drinking paracetamol in the following article.

Paracetamol side effects can appear if consumption exceeds the recommended dose, which is more than 4,000 mg per day in split doses for adults, and exceeds 15 mg/kg of BB per dose for children.

Compiled from various sources, here are the excessive side effects of drinking paracetamol that need to be known.

According to the United States Food and Drug Administration (FDA/Food and Drug Administration), drinking too much paracetamol can cause liver damage, quoted from Healthline.

However, the difference in safe paracetamol doses and doses that can damage the liver are very small. Experts agreed to reduce the maximum daily dose recommended to 3,000 mg per day in split doses.

The risk of these side effects will increase if you already have liver function disorders, consumption of alcoholic beverages more than 3 times in a healthy manner, or if you consume warfarin (blood dilution drug).

In more severe cases, paracetamol overdose can cause liver failure or death.

Adapting the British Liver Trust page, here are the symptoms of liver damage due to a paracetamol overdose:

In rare cases, drinking paracetamol exceeds the recommended dose can cause kidney failure.

At a therapeutic dose of 500 mg to 2,000 mg, as many as 5-15 percent of this drug is generally converted by the 450-in-heart cytokrim enzyme into its reactive metabolite called N-acetyl-p-benzoquinoneimimine (NAPQI).

This process is referred to as metabolic activation and NAPQI functions as free radicals that have a very short life.

Under normal conditions, NAPQI will be quickly detoxified by glutation enzymes of the day. This enzyme contains a sulfhidril cluster that will covalently bind radically free NAPQI and generate a sinstein conjugate.

However, excessive intake of paracetamol makes it difficult for the kidneys and liver to detoxify NAPQI. As a result, NAPQI causes intracellular damage followed by necrosis (cell death) of the liver and can also cause kidney failure.

For additional information, symptoms of a paracetamol overdose do not appear immediately. In fact, there may be no symptoms at all up to 24 hours after the overdose. It is important to record the time of consumption of paracetamol, and in what form (ruption, tablets, capsules/tablets off slowly or suppositoria).

Paracetamol is available in the form of tablets, capsules, liquids, and suppositoria. This drug is also formulated according to the patient's age, so the rules for using adults will be different from children.

Congested is a dose of paracetamol recommended to relieve fever or as a pain reliever:

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