JAKARTA - The National Research and Innovation Agency (BRIN) conducted research on active compounds derived from serei oil as candidates for raw materials for anticancer drugs.
Researcher of the Intermediate Research Center for Drug and Traditional Medicines BRIN Galuh Widiyarti said the series contains soapyl and geraniol compounds that have several activities as antibacterial, anti-ageur, antiparasitic, and cytoxic to several cancer cells.
"The research is expected to increase Indonesia's independence in producing medicinal raw materials from medicinal plants to support the development of the Indonesian pharmaceutical industry and open up opportunities for cooperation with the atsiri and pharmaceutical industries," he said in a statement quoted by ANTARA, Thursday, May 25.
BRIN conducted research by making derivatives of compound ester, namely ester soapyl and geraniol. The two compounds were then docking Pim1 kinase with MVD and 6frb docking with 4.2.
If the rerankskordocking is lower than the anti-sateronol and geraniol ester compounds, it will be further synthesized.
The synthesis results produce cytronol and geraniol esterification by utilizing the content of carboxylic acid contained in palm oil, refining, being identified, and conducting toxicity tests using BSLT and vitro-like cytoxy tests of MCF7 cancer cells (natural blue) and selfo(MTT).
Some of the results of the study, the ester of soaprollol and geraniol, the results of synthesisitotoxic synthesis of the P388 ferrochemical murine cancer cell, the aliphatic ester compound (the neutronelbaru period) has the potential as an anticancer compound and analysis of the nature of ADME and drug likeness has the potential as a drug candidate.
In-siliko studies using the AutoDock 4.2 program show that ester (CIB and GIB) has the potential to be antimicrobial.
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The results of the vitro test show that both ester compounds have stronger antimicrobial activity compared to acid compounds so that the two ester compounds have the potential to be further developed into antibiotic compounds.
The results of the study provided new hope for obtaining raw materials for breast anticancer candidates and antibiotics from the derivatives of serei oil to help solve the problem of antibiotic resistance.
"The study must be developed because it requires a lot of research to support the results of the study," he said.
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