Is Amenorrhea Dangerous? Here's The Explanation

Is Amenorrhea Dangerous? (A picture of Sherise Van Dyk - Unsplash)

YOGYAKARTA - Chemotherapy-induced Amenorrhea (CIA) is a cessation of menstruation in one year after starting chemotherapy and synergizing for up to 12 months or more. CIA is one of the long-term side effects of chemotherapy on breast cancer that can affect future reproduction. Amenorrhea itself is a term for not menstruating or menstruating.

Breast cancer is a violent disease that is often encountered in all parts of the world. Chemotherapy can share significant life expectancy in people with early-stage breast cancer. However, chemotherapy can have many side effects, such as the CIA.

Approximately 25% of breast cancer is diagnosed in women who are not yet menopause and approximately 15% are in women under 45 years of age. The CIA's early diagnosis

at this time more often is found because the proportion of breast cancer survivors continues to increase along with the development of therapy.

Cause

Various chemotherapy drugs that can cause the CIA according to the level of risk can be shared as follows:

Melanesia dhaturi ai-care,id, Several studies show that CIA events correlate with several factors such as the type of chemotherapy used, duration of chemotherapy, dose of chemotherapy, patient age, pregnancy history, and the presence of hormonal therapy.

Amenorrhea risk due to chemotherapy with multiple drug regimes ranges from 21% to 71% in young women, and 49% to 100% in women over 40 years of age. Usually, older women are at higher risk of experiencing CIA due to reduced number of active egg follicles in egg protections that occur with age.

Women who experience their first menstruation at the age of >13 years have a twice as high risk of experiencing the CIA.

The number of CIA incidents has increased significantly in patients who are also undergoing hormonal therapy, for example with a Tamoxylene and having a tumor with a positive ER (estrogenceptor).

A study shows that in patients with a high body mass index (weight excess), it is more likely to experience a permanent CIA. However, this is still controversial.

Chemotherapy can cause spinal cord damage, where blood cells are produced, including white blood cells. This will cause leukopenia or decreased leukocytes (white blood cells), especially in patients aged (over 40 years). Leukopenia that occurs after the first cycle of chemotherapy is associated with increasing CIA risk. This means that leukopenia can be an early predictor of fertility disorders due to chemotherapy.

Can Cause Complications

The CIA can cause an early menopause, which will interfere with fertility and reduce the quality of life of the sufferer.

Early Menopaus can increase the risk of osteoporosis, heart disease of blood vessels, and other problems.

When Do You Have To Go To A Doctor?

If you are undergoing chemotherapy or have undergone chemotherapy and have menstrual disorders, one of which is amenorrhea where you are no longer getting menstruation for 3 consecutive cycles, then you should consult a doctor to get further treatment.

This is especially important if you are a woman under 45 years of age or have not experienced menopause and still want pregnancy. Because chemotherapy can also cause premature menopause and fertility disorders that can seriously affect the quality of your life, it is important for doctors to investigate your risk factors for CIA so that appropriate therapy regimes can be given.

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