Allegedly Being A Bit OfROok Years Of Acute Cells In Children, What Is Ethilen Glikol?

Illustration ofgalous products contaminated with glycol ethylene (Unsplash)

YOGYAKARTA Recently, the Indonesian people have been shocked by cases of acute kidney failure in children suspected of being caused by glycol ethylene. In the Ministry of Health's report, glycol's ethilen has polluted 15 of the 18 drug products being identified. So, what is glycol's ethylene?

Previously, the glycol ethilenic compound was also suspected to be the cause of the death of 66 children in Gambia, West Africa.

Based on laboratory analysis, there are fourORD products that are contaminated with glycol etylene with content that exceeds the normal limit. The fourgalung products are Promethazine Oral Solution, Kofexmalin Baby COugh Syrup, Makoff Baby Cough Syrup, and Magrip N Cold Syrup.

The Indonesian Food and Drug Supervisory Agency (BPOM) has confirmed that the four▁besarung products produced by Maiden Pharmaceutical Ltd, India, are not circulating in Indonesia.

What is Ethilen Glikol?

According to the National Center for Biotechnology Information (NCBI), glycol ethilen (C2H602) is a toxic alcoholic' which is often used by the household industry. The term oximous alcohol' refers to several types of alcohol such as methanol and alcohol isophopil.

The giving of glycol ethylene is colorless, odorless, has low viscosity, causing higroscopic fluids. This fluid can provide a sweet taste.

In the pharmaceutical industry, glycol ethylene is sometimes used as an additional substance solvent.

The World Health Organization (WHO) stated that glycol ethylene can have a toxic effect if consumed by humans. Some of the symptoms that may arise after consumingulants or other preparations exposed to glycol ethylene include:

Meanwhile, according to the Professor of the Faculty of Pharmacy, Padjadjaran University, Prof. apt. Muchtaridi, Phd, ethile glycol when entering the body, will have oxidation by enzymes so that it becomes glycol aldehyde.

Glikol aldehyde then returned to dioxide to glycolic acid and reshaped into oxal acid. This compound is the trigger for the formation of kidney stones.

Muchtaridi added, oxal acid that has crystallized will be shaped like a sharp needle. "Small soluble oxalas are small, if you meet calcium, salt will form which is difficult to dissolve and run into organs such as bile and kidneys. If you run to the kidneys, you will become a kidney stone. The crystal will sharply injure the kidneys," he said, quoted by VOI from the official website of Padjadjaran University, Thursday, October 20, 2022.

Ethilen Samping Effect Glikol

Etilen glykol will have dangerous side effects if consumed by anal-child. The reason is, the size of the children's kidneys is much smaller than that of adults.

In addition to damageing the kidneys, the eethylene side effects of glycol can run to the heart and trigger rapid death. "The most dangerous thing is when this condition occurs in dry countries. The condition of dehydration will accelerate the formation of oxalic acid. Examples are like in Gambia," said Muchtaridi.

Because it can cause dangerous side effects, the use of glycol ethylene has been banned by the Food and Drugs Administration (FDA).

In line with the FDA, Farmakope Indonesia also prohibits the use of glycol ethilen for drug formulation. However, glycol ethilen has the potential to be found in the form of contaminants in additional ingredients for preparingORps with a tolerance value of 0.1 percent in glycerin and glycol propylene glycol and 0.25 percent in polyethylene glycol.

That's the information about what glycol's ethilen is. May it be useful!