Research Shows Fasting Reduces Inflammatory Risks That Cause Diseases

YOGYAKARTA When you don't fast, you can eat three times or more heavily a day. Fasting is generally done to reduce weight. Along with the fasting moment of Ramadan, in addition to fasting, fasting is beneficial for health. Research published in the journal Cell Reports shows evidence that fasting is good for the body. When fasting, the body uses stored fats and carbohydrates as a source of energy. In the context of research showing the benefits of fasting, researching about fasting and its effects reduce the risk of inflammation.

Experts say that inflammation or inflammation causes various chronic diseases. One of them is metabolic syndrome that increases the risk of type 2 diabetes, heart disease, and obesity. In some cases, inflammation may cause the body to survive against viruses, bacteria, and other organisms that cause infection. But sometimes the body mistakenly considers knowing the tissue so that this response can be dangerous because it can cause autoimmune diseases, such as type 1 diabetes and inflammation of the gut.

Researchers in this latest study say that eating high-calorie foods is related to chronic metabolic inflammation syndrome, called metainflammatory. Metainflammatory underlies many non-communicable diseases commonly experienced. Reported by Medical News Today, Thursday, March 13, this study reports that the increase in protein levels of interleukin immune response (IL)-1UL, NLRP3 inflammatory activity, and systemic inflammation are characteristic of chronic metabolic inflammation syndrome.

Reports also note that exogenous aridydonate acid can interfere with NLRP3's inflammatory activity in macrophages of humans and mice. Researchers sample serums from 21 volunteers, who consume 500 kilokalori basic foods, fast for 24 hours, and then consume 500 kilokalori more foods. In monuclear cells of edge blood (PBMC) from these volunteers, IL-1 tariff levels increased 3 hours after eating the second. Plasma aridydonate acid increased in volunteers during fasting but decreased after eating the second. In fasting participants, compared to other participants with a more normal eating plan, lower plasma IL-1 plasma and higher ariidonat acid. Ariidonat acid inhibits C phosfolipase and reduces JNK stimulation and NLRP3 activity, they said.

Please note, metainflammation is a complex process that involves an integrated network and systemic specific immune response in addition to metabolic regulation. Researchers say fasting helps suppress metabolic inflammation and is characterized by a decrease in serum pro-inflammatory cytokines, in particular the so-called interlucines closely related to insulin regulation and glucose levels.

"Food patterns rich in saturated fatty acids, such as palmite acid or stearatic acid, also trigger NLRP3 inflammatory activity," said the researcher.

A dietist who was not involved in this study, Ro Huntriss, said that araardionic acid, non-saturated fatty acid, may be an important physiological regulator of metabolic inflammation. This araardionate acid, obtained from eating meat, poultry, and eggs, explains Huntris. Then stored as a phospholioid component in the cell membrane.

"They -the researchers found that NLRP3 activity then increased when volunteers ate food again. Therefore, the research provided a potential mechanism that explains how fasting reduces inflammation," he said.

This study reports interesting findings, Huntris comments. While medical and hematological oncologist Doctor Luke Chen said chronic inflammation effects have been more serious and clearer in recent years. People who have chronic inflammation and ulserative collitis and Crohn's disease, for example, have a higher risk of developing colorectal cancer, Chen's class.

In addition to getting the benefits of fasting, it is also important to maintain daily healthy intake. This is important so that the body still gets adequate energy to be able to stay active.