Getting To Know The PDRN Skincare Trend, Benefits And Side Effects

JAKARTA - One of the skincares that is currently viral on social media is PDRN or Polydeoxybonucleotide. Scientifically, PDRN is a DNA fragment extracted from salmon sperm, which turns out to have a very similar structure to human DNA.

Based on salmon DNA, PDRN is widely known for its ability to repair and reorganize the skin. In South Korea, this skincare has been widely used, such as the Healer Rejuran Aesthetic medical procedure, injection treatment known as the treatment skin booster.

Quoted from the Singapore Vogue, dermatologist consultant, Dr. Stephanie Ho, explained that there are indeed several benefits from PDRN. One of them is skin regeneration, by stimulating cell change and repairing skin tissue.

This skincare can also provide anti-aging by increasing collagen production, hydrating the skin intensively, providing anti-inflammatory, hubong rejuvenation effects thoroughly so that the skin looks healthier and more glowing.

In 2025, PDRN began to penetrate the world of topical skincare. The formulation is in the form of serum, cream, to sheet masks.

These products are claimed to make the skin more chewy, moist, and look like glass skin. However, if used in topical skincare, the function of PDRN depends on the formulation of the product.

"The science behind PDRN is promising, especially in aesthetic care where it is injected directly into the skin. But if it is inserted into topical skin care, its efficacy depends on the formulation and the molecular delivery system," explained Stephanie Ho, quoted on Thursday, April 17, 2025.

Stephanie Ho also suggested using PDRN from the age of 25 years and over. At that age, collagen production usually decreases naturally.

In addition, it is also necessary to pay attention to some of the side effects of using PDRN. One of them is for those who are allergic to seafood, because PDRN comes from salmon DNA, so that allergies should be avoided.

Then, this skincare should not be used during pregnancy or breastfeeding, because there is not enough study that confirms that the safety of pregnant and lactating women is used. Although it is good for acne scars, PDRN should also not be used on the skin with active acne or infection.